Now weve lost the high ground, Morris told me. So much for evidence-based medicine. Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. Dr. Seftel is an NIH-funded researcher and an NIH reviewer. Three of the four outpatient trials have been reported out: all were successful. Im taking low dosage Fluvoxamine as part of a multi-drug FLCCC protocol to alleviate some mild brain fog. reach out to us at Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. I've collected fluvoxamine evidence here for convenient access. If you have trouble getting a prescription, perhaps you have OCD? I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. Here's why. Physicians who use the drug for COVID now swear by it. Once the Phase 2 result came out, it should have been embraced by doctors. This 1/6 of the dose the FDA has approved for OCD (the labelled indication for fluvoxamine)! They immediately ruled out the vaccine, because the vaccine is, quote, safe.. (article I did after the TOGETHER trial). Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. skirsch.io Steve Kirsch Home page. He was recently featured on 60 Minutes which highlighted his . Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. We could have saved a lot of lives. 33. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. Medicine today isnt about saving your life. . Last Checked: 03/02/2023. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. But they dont want their names used. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to completely avoid the list in the previous paragraph, or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). 1:49 , or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). The differences are obvious to untrained eyes. 12:45 AM . All the supporting observational studies were positive as well. Expect similar things to happen when Eiger applies for an EUA for interferon lambda, a drug with a 89% efficacy in phase 3 trials. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Dr. Eric Lenze: So the results were really pretty. Dosing. Hes also publicly railed against what he claims is a campaign against drugs like fluvoxamine and ivermectin. He said of his study, This is the most extraordinary effect Ive seen in my 25 years practicing medicine.. Stopping the meds will return you to your normal self. He has been a medical philanthropist for more than 20 years. Fluvoxamine has a 40 year safety track record. Ivermectin has a very high quality systematic review, the highest possible level in Evidence Based Medicine. This advice is now outdated. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls, she said. In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. customer-service@technologyreview.com with a list of newsletters youd like to receive. These people never called the researchers whose trials they claimed showed no effect. In two trials (both published studies in peer reviewed journals with Editor's Choice in both cases), the drug had a 100% effect size in protecting against hospitalization from the respiratory symptoms from COVID. If you continue to get this message, It was so bad you couldnt even see the babys body through all the blood, Kirsch said. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. In severe cases, it takes longer. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Other drugs in this class include Prozac (fluoxetine), Zoloft (sertraline) and Paxil (paroxetine). It will be months before enrollments are complete. Discover special offers, top stories, Quick Summary . Most doctors wont use it until NIH greenlights it, no matter what the science says. We have a bounty of vaccines and more on the way, but drugs that treat the disease are vital too if we want to keep people alive and bring the pandemic under control. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. You can use fluoxetine as well (aka Prozac). It was 25 years ago yesterday that Andrew Wakefield launched the modern iteration of the antivaccine movement.In doing so, he laid down a template that antivax quacks today still follow. . If you cant lay off the java, then try fluoxetine (Prozac). The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. I must admit that this is an anniversary that snuck [4] Steve Kirsch - Silicon Valley Philanthropist Shares Review of CDC Data: COVID-19 Vaccine Associated with 100X Deaths Compared to Influenzas [5] Steve Kirsch - FOIA Document for Vaccine Discussion as to mRNA-based Vaccine Safety Signals Added 12th August 2021: When you need to characterize me, you need to say that Steve Kirsch doesnt go with majority votes on interpreting data, he told me when I asked about his views on ivermectin, which he insists is a silver bullet against covid. Author Affiliations . The post read: "I will be featured on 60 Minutes this Sunday talking about fluvoxamine as an effective treatment for COVID-19 to prevent hospitalization and death. Get your prescription in advance of getting COVID. Items included in the Television News search service. This is why Cliff doesnt talk to me. Now they turn to Rust. Note that a total of 77 people got the drug, not 65. It doesnt get any better than this. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. Medium revoked my account for life. He told me that while he and his family got vaccinated as soon as they were eligible, he got the idea that vaccines are dangerous from a man he hired to clean his carpets, who got very sick after receiving the vaccine. Thats pretty typical, but your mileage may vary. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. Silence from the medical community. In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. The rest of the board soon followed. There are 4 outpatient studies that have been done (2 at WashU (see Phase 2 trial results published in JAMA), one in Berkeley, CA by David Seftel, one in Brazil published in the Lancet, and one in-patient study done in Croatia. That trial has now been completed, and the researchers are analyzing their data. Why fluvoxamine isnt used. Kirsch and his wife, Michele, fund a charitable foundation, which by 2007 had given $75 million to different causes. They left their recommendation of fluvoxamine at NEUTRAL. David Boulware, a researcher at the University of Minnesota, received $125,000 to test the drug against covid. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! My experience is very typical. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. The medical community doesnt care about saving lives. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. 47).. That way you can start immediately. So the drug had no chance of working (since there were no events), so the trial was stopped for futility, NOT because the drug doesnt work. Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. Medicine isnt about saving lives anymore. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Online Status. The findings, published Wednesday in the New England Journal of Medicine, add to a growing body of scientific evidence pushing back against the use of the antiparasitic drug that has been promoted by some prominent voices on social media. And FrameMaker is still a niche product. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. Doctors have no excuse for not prescribing. Theres nothing there.). But the confusion provided a fertile breeding ground for skeptics. One of the first CETF grants was to investigate the antimalarial hydroxychloroquine. Always be self aware when using fluvoxamine. more time. Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. While Fauci was crafting national pandemic policies, Fauci's wife [Christine Grady, Chief Bioethicist, NIH] was back stopping [them]." Report coming soon. Its all about NIH saying it is OK. Medicine today is driven by government opinion, not science. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008 Google Docs This is a more comprehensive look at the key evidence supporting fluvoxamine: Fluvoxamine for COVID-19 February 17, 2021. . Why not fluvoxamine? Thanks to the volumes of data and information provided by pharmaceutical companies and regulators, as well as large numbers of trials from independently funded research groups around the world, I now trust that theyre safe for the vast majority of adults. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? He retired at the largest pension in federal history. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. Its actually much harder to parse out a signal than if youre treating diabetes or cancer., In addition to the issues with fluvoxamine, advisors grew increasingly uncomfortable with Kirschs posts about ivermectin, which he has repeatedly claimed in blog posts and appearances in alternative media can be used together with fluvoxamine to prevent 100% of covid-19 deaths. Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. Steve Kirsch Executive Director at COVID-19 Early Treatment Fund (2020-present) Author has 176 answers and 1.7M answer views Updated 1 y Both. [NIH] doesnt want any of these treatments. Avoid caffeine, benadryl, tylenol, and alcohol. What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. I disagree with his interpretation of the data regarding several medicines and strongly disagree with his anti-vaccine nonsense, Boulware wrote to me. The results would, eventually, set Kirsch on a collision course with the scientific establishment. He has made millions from these projects, even if they have not turned him into a household name. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. Hes probably the closest thing Kirsch has to a nemesis, regularly disputing his assertions in blog posts and private email exchanges with Kirsch and his friends. Los Altos Hills resident Steve Kirsch funded research into the drug fluvoxamine as a treatment for COVID-19. In November, CETF gave the group an additional $500,000 for a phase 3 clinical trial that might show conclusive proof of efficacy. Hes adept at debate, rapidly shifting the premise of a conversation to put the other person on the back foot. Hilary Grant-Valdez Operations Manager Tom Brunner He has been a medical philanthropist for more than 20 years. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. Why the FDA should grant an EUA for fluvoxamine immediately, Links to evidence about fluvoxamine including the public data repository, Here's the first one: (Clayton Fox, Marty Makary, and Jeffrey Klausner). The track management was so impressed, they asked for prescriptions. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). Doctors who are most familiar with the drug would prescribe it to their patients. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. My favorite dosage is 50mg twice a day for 14 days. This document is a collection of evidence that highlights the glaring errors in our pandemic response. Indeed, some of the most prominent people spreading misinformation about ivermectin and vaccines today began by promoting hydroxychloroquineincluding by claiming to debunk Boulwares data analysis. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. Their willingness to lie did. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). Where did it go wrong. Once the Phase 2 result came out, it should have been embraced by doctors.
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